Multimodal Diagnostic Approach in Cardiac Myeloid Sarcomas
Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND: Myeloid sarcomas are rare extramedullary infiltrations of immature myeloid cells seen in leukemic, myeloproliferative, and myelodysplastic syndromes. Cardiac infiltration of these cells clinically manifest based on the heart anatomy that is affected. CASE SUMMARY: A 61-year-old male with significant history of acute myeloid leukemia status post hematopoietic stem cell transplant, left renal myeloid sarcoma status post chemoradiation, and left eye myeloid sarcoma status post chemoradiation was found to have new cardiac myeloid sarcomas (CMS) after presenting with subacute chest pain and new onset of atrioventricular nodal disease on electrocardiogram. DISCUSSION: While obtaining an endomyocardial biopsy is the gold standard for diagnosing CMS, multiple diagnostic modalities can be used to determine the presence of them. TAKE-HOME MESSAGE: While CMS is rare, it is important to follow through with a multimodal diagnostic approach to clarify the diagnosis in the at-risk malignant hematological population when presenting with new or changing cardiac clinical presentations.
Source: JACC Case Reports
Authors: Luis A. Ortiz, Onyee Chan
Institutions: University of South Florida, Moffitt Cancer Center
Language: English
Topic: Cardiac tumors and thrombi
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $850
OpenAlex ID: W4413011565