Work

Light-triggered toll-like receptor activation in a nanoscale metal–organic framework for synergistic PDT and cancer immunotherapy

Year: 2025

Type: article

Abstract: a ROS-sensitive linker for combined PDT and immunotherapy. Upon light irradiation, the DBP photosensitizer within the MOF generates both singlet oxygen and hydroxyl radicals, enabling simultaneous induction of PDT and triggered release of R848. This dual-function platform effectively induces cancer cell death and suppresses tumour growth in colon cancer models, demonstrating its potential as an on-demand and synergistic cancer immunotherapy strategy.

Source: Chemical Science

DOI: 10.1039/d5sc03446a

Authors: Yibin Mao, Langston Tillman, Xiaomin Jiang, Wangqing Bian, Chaoyu Wang, Tobias Fromme, Ralph R. Weichselbaum, Wenbin Lin

Institutions: University of Chicago, Technical University of Munich, Else Kröner Fresenius Zentrum für Ernährungsmedizin

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Cancer Institute

Awards: Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck Cancers, G5739243289, G6284950015, G9000133030

OpenAlex ID: W4413021815

FWCI: 2.345

Cites: 39

Cited by: 10

Related to: 10