Work

Functional Polylactide Micelles for Targeted Delivery of Paclitaxel

Year: 2025

Type: article

Abstract: The aim of this work was to study the potential of magnetosensitive polylactide micelles (PLMs) for creating nanocontainers for targeted delivery of hydrophobic paclitaxel. After solubilization of paclitaxel and magnetic particles, the PLMs retain a size acceptable for use as a dosage form and demonstrate magnetosensitivity and colloid stability. The resulting nanosystems remain biodegradable. Thus, owing to the ability to include maghemite nanoparticles and hydrophobic drugs simultaneously, PLMs are promising for creating magnetically sensitive systems for targeted drug delivery.

Source: INEOS OPEN

DOI: 10.32931/io2524a

Author: V. A. Pigareva

Institutions: Russian Academy of Sciences, A. N. Nesmeyanov Institute of Organoelement Compounds

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Ministry of Science and Higher Education of the Russian Federation