Work

The Role of Drug-Induced Sleep Endoscopy with Positive Airway Pressure Titration in the Individualized Treatment of Obstructive Sleep Apnea: A Report of Three Illustrative Cases

Year: 2025

Type: article

Abstract: Purpose: Drug-induced sleep endoscopy with positive airway pressure titration (DISE-PAPT) can assess the effect of varying positive pressure levels on upper airway collapse in patients with obstructive sleep apnea (OSA) under simulated sleep condition. But it remains unclear whether DISE-PAPT can facilitate the development of personalized therapeutic interventions for OSA and further improve the therapeutic efficacy. Patients and Methods: We present three adult patients with severe OSA exhibiting distinct clinical profiles: one case of continuous positive airway pressure (CPAP) treatment failure, one case of intolerance to high CPAP, and one case of psychological resistance to CPAP therapy. Results: According to the DISE-PAPT evaluation findings, CPAP combined with positional therapy was administered in Case 1. CPAP with surgical management was performed in Case 2, resulting in significant therapeutic improvements. Additionally, real-time DISE-PAPT visualization of CPAP-mediated upper airway patency restoration enhanced CPAP adherence in Case 3. Conclusion: The personalized treatment strategies based on the DISE-PAPT technique hold promise for improving the overall therapeutic efficacy and adherence among patients with OSA.

Source: Nature and Science of Sleep

DOI: 10.2147/nss.s539613

Authors: Pei-Jun Li, Lin-Jing Gong, Zi-Yang Huang, Xiang Zhang, Dan Liu, Zong-An Liang

Institutions: Sichuan University, West China Hospital of Sichuan University, West China Medical Center of Sichuan University

Language: English

Topic: Obstructive Sleep Apnea Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836