Work

DCUN1D2 is insignificant for spermatogenesis and male fertility in mice

Year: 2025

Type: article

Abstract: OBJECTIVES: Defective in cullin neddylation 1 domain containing 2 (DCUN1D2) belongs to the DCNLs family and can induce cell growth arrest and is also related to neddylation. While its potential role in spermatogenesis is hypothesized, the functional significance of DCUN1D2 in male germ cells remains undefined. METHODS: -knockouts were generated. Sperm parameters were analyzed via computer-assisted sperm analysis (CASA), while histological and immunofluorescence staining were employed to evaluate spermatogenic progression and apoptosis. RESULTS: conditional knockout (cKO) mice exhibited no significant differences in histology, semen quality, sperm apoptosis or fertility tests. CONCLUSIONS: This study indicated that DCUN1D2 has no significant effect on mouse spermatogenesis or male fertility. These findings will help avoid redundant studies and provide new information for the study of human fertility genes.

Source: American Journal of Translational Research

DOI: 10.62347/clig5523

Author: Yuxuan Feng

Institutions: State Key Laboratory of Reproductive Medicine, Nanjing Medical University

Language: English

Topic: Sperm and Testicular Function

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4413025692

FWCI:

Cites: 38

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Related to: 10