Work

A Major Facilitator Superfamily Transporter Is Critical for the Metabolism and Biogenesis of the Apicoplast

Year: 2025

Type: article

Abstract: The apicoplast is a highly specialized organelle in the biosynthesis of essential metabolites in most of the apicomplexan protozoa. This organelle is surrounded by four layers of membranes. However, the molecular mechanisms mediating transmembrane transport are not yet fully understood. In this study, we conducted a phenotypic analysis to investigate the role of a major facilitator superfamily transporter (TgApMFS1) in the survival of the parasite. The results indicated that TgApMFS1 is critical for the survival of Toxoplasma gondii in cell culture conditions. Further analysis indicated that these transporters are crucial for the biogenesis of organelles and the metabolic processes of parasite.

Source: Pathogens

DOI: 10.3390/pathogens14080763

Authors: Yumeng Liang, Wei Qi, Jiawen Fu, Honglin Jia

Institutions: Chinese Academy of Agricultural Sciences, Harbin Veterinary Research Institute

Language: English

Topic: Toxoplasma gondii Research Studies

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,654