Year: 2025
Type: article
Abstract: GNA13, a component of the G protein signaling network, is involved in regulating cancer cell growth, migration, and programmed cell death. Recent evidence has shown increased levels of GNA13 across several tumor types, including breast, prostate, stomach, and liver cancers, closely linking its expression to tumor progression, spread, and patient outcomes. This article systematically reviews GNA13 expression across diverse cancers and explores its functional impact on tumor biology. Particular attention is given to the pathways through which GNA13 enhances cancer progression, specifically by stimulating AKT, ERK, and MYC signaling and suppressing FOXO1. Current research identifies GNA13 as an emerging biomarker and potential target for cancer diagnosis and therapy, paving the way for future treatment innovations.
Source: Biomedical Data Science
Author: Xu Wang
Institution: Northwest A&F University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4413026561