Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction. Merkel cell carcinoma (MCC) is a clinically rare primary neuroendocrine carcinoma of the skin, which is more prevalent in the head and neck but rare in the eyelid. In clinical practice, it is characterized by a high misdiagnosis rate, high degree of malignancy and extremely poor prognosis. At present, there is no matured and effective treatment plan for MCC. Case outline. This case study retrospectively reports a patient experiencing MCC of the eyelid in Tangshan Ophthalmology Hospital. One month after tumor resection, the patient experienced cervical lymph node spread on the same side. Following chemotherapy, no abnormal lesions were found during a follow-up of two years and three months. Conclusion. The case study demonstrates that MCC is diagnosed mainly based on pathological examination and treated with surgical resection as the preferred option. In addition, postoperative adjuvant systemic chemotherapy and local radiotherapy have an inhibitory effect on the disease?s metastasis and recurrence. Immunotherapy and molecular targeted drugs are the new development trends.
Authors: Xiao-Rui Zhou, Ming-Rui Gao, Ming-Hua Yan, Cheng-Lin Dai
Institution: Tangshan People's Hospital
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413034775