Work

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults (Adv. Sci. 29/2025)

Year: 2025

Type: article

Abstract: A Cascade Strategy for Hepatocellular Carcinoma In article number 2501420, Yingjie Zeng, Jun Lu, and co-workers present a tumor microenvironment-responsive hybrid nano-prodrug (CA-4S2@ES-Cu) that achieves spatiotemporal co-delivery of CA-4 (angiogenesis inhibitor) and ES-Cu (mitochondrial cuproptosis inducer). Synergistic GSH depletion amplifies oxidative stress and DAMPs release, activating immunogenic cell death to transcend monotherapy limitations, thereby establishing a multidimensional therapeutic paradigm for hepatocellular carcinoma.

Source: Advanced Science

DOI: 10.1002/advs.71032

Authors: Yingjie Zeng, Yuening Cao, Senmiao Ren, Chaozheng Zhang, Jianan Liu, Ke Liu, Yan Wang, Hongyu Chen, Fengjiao Zhou, Xiuli Yang, Xian Ge, Tingting Zhang, Tianbao Wang, Yao He, Defang Li, Chuantao Zhang, Jun Lu

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730

OpenAlex ID: W4413040962

FWCI:

Cites:

Cited by:

Related to: 10