Year: 2025
Type: article
Abstract: work demonstrating that glucagon signaling activates glycogenolysis in hepatocytes. This model has been extended to implicate glucagon in diabetogenesis, positing that the increased secretion of glucagon acts as a primary driver of hyperglycemia. However, recent work suggests an alternative set of actions for glucagon, including stimulation of insulin secretion and enhancement of hepatic insulin action. These recent findings align with the results of clinical trials using novel drugs that activate the glucagon receptor as part of a multi-receptor mechanism of action. Taken together, it appears that glucagon has distinct actions in the fed and fasted states, and glucagon receptor agonism has potential as a therapeutic approach to the treatment of diabetes.
Source: PubMed
Author: David A D'Alessio
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4413048361