Work

Quantification of laser-induced aerosols by microdroplet calibration and investigation of matrix effects using LA-ICP-TOFMS

Year: 2025

Type: article

Abstract: solution nebulization, suggesting a fundamentally different behavior of microdroplets in the plasma. Radial diffusion profiles were acquired to assess in-plasma behavior of droplets and laser-induced aerosol from NIST SRM 610 (glass). Diffusion profiles overlapped and showed similar full width at half maxima (FWHM) for microdroplets and the laser-induced aerosol, with minor spatial shifts in intensity maxima, likely due to not complete on-axis droplet introduction into the plasma. Quantification based on microdroplet calibration yielded relative deviations from reference values below ±20% across certified reference materials and an in-house prepared gelatine standard. Quantification of gelatine samples using NIST SRM 610 (glass) as an external standard resulted in larger deviations compared to droplet-based calibration, which yielded values in agreement with digestion data. These results demonstrate the suitability of monodisperse microdroplets for non-matrix-matched calibration in LA-ICP-TOFMS, particularly for elements non-certified or uncommonly reported in reference materials used in LA-ICP-MS.

Source: Journal of Analytical Atomic Spectrometry

DOI: 10.1039/d5ja00171d

Authors: Tobias Schöberl, Mirjam Bachmann, Detlef Günther

Institutions: ETH Zurich, Laboratory of Inorganic Chemistry

Language: English

Topic: Analytical chemistry methods development

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Awards: G7434391795, G993971353