Work

A FABulous Couple: Adding PHENotype to GENotype Improves HMA/VEN Response Prediction in AML

Year: 2025

Type: article

Abstract: In a large retrospective multicenter study of patients with acute myeloid leukemia treated with hypomethylating agents and venetoclax, Lachowiez and colleagues examine the interplay among genetic mutations, disease phenotype, and clinical outcomes. They show that within genetic subgroups-particularly NPM1 wild-type cases-monocytic differentiation is linked to poor treatment response and inferior long-term prognosis, adding a phenotypic layer to genetics-based response prediction. See related article by Lachowiez et al., p. 437.

Source: Blood Cancer Discovery

DOI: 10.1158/2643-3230.bcd-25-0174

Authors: Simon Renders, Alexander Waclawiczek, Andreas Trumpp

Institutions: German Cancer Research Center, Heidelberg University, University Hospital Heidelberg, DKFZ-ZMBH Alliance, Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Deutsches Konsortium für Translationale Krebsforschung

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4413051399

FWCI: 1.308

Cites: 11

Cited by: 2

Related to: 10