Work

End group chemistry modulates physical properties and biomolecule release from biodegradable polyesters

Year: 2025

Type: article

Abstract: MPs and slightly accelerated from PLGA-OH MPs, compared to PLGA-COOH MPs. These studies provide further insight into the interactions between charged biomolecules and the encapsulating polymer and could provide additional tools to tune release for various protein therapeutics that experience such interactions.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d5tb00816f

Authors: Matthew A. Borrelli, Jordan J. P. Warunek, Tarini Ravikumar, Stephen C. Balmert, Steven R. Little

Institutions: University of Pittsburgh, McGowan Institute for Regenerative Medicine

Language: English

Topic: biodegradable polymer synthesis and properties

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Funders: American Heart Association, University of Pittsburgh, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: G1039939978, G2580383538, Local enhancement of regulatory T cells for the treatment of myocardial infarction, G9000043562, G9000342753