Work

Target‐Mediated Drug Disposition Revisited: Michaelis–Menten Approximations for Bivalent Drug Molecules

Year: 2025

Type: article

Abstract: The Michaelis-Menten (MM) approximation of the target-mediated drug disposition (TMDD) model is often used to describe nonlinear pharmacokinetics of monoclonal antibodies, which are, however, bivalent molecules. We analyze a TMDD model for bivalent drugs by means of quasi-steady state approximations, which yield MM approximations in the limit of weak avidity (soluble targets) and strong avidity (cell surface targets), thereby providing a justification for the use of MM approximations for bivalent drugs with slow systemic clearance.

Source: CPT Pharmacometrics & Systems Pharmacology

DOI: 10.1002/psp4.70094

Author: Ronny Straube

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,140

OpenAlex ID: W4413054975

FWCI: 1.071

Cites: 6

Cited by: 2

Related to: 10