Work

The effect of Polyvinylpyrrolidone-Sodium hyaluronate gel on palatal wound healing: a randomized controlled clinical trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND: ) on palatal wound healing, pain, and bleeding following free gingival graft surgery (FGG). METHODS: and chlorhexidine mouthwash, while the control group received only chlorhexidine. Patients were called at first, third, seventh, fourteenth and twenty-eighth postoperative days and, Visual Analog Scale (VAS), Wound Healing Index (WHI), hydrogen peroxide (H₂O₂) bubbling scores and bleeding situations were recorded. The Friedman test was used for repeated measures, with the Wilcoxon signed-rank test as post-hoc, and the Mann-Whitney U test for between-group comparisons. RESULTS: H₂O₂ test values significantly decreased and WHI values significantly increased over time in both groups (p < 0.050). Test and control groups comparison at time points showed the test group showed significantly lower H₂O₂ test values on days 7, 14, and 28 (p < 0.050) and higher WHI values on days 3, 7, 14, and 28 compared to control group. VAS pain, chewing, and burning scores were also significantly lower in the test group on days 1, 3, 7, and 14 compared to control. While on day 1, the control group had a bleeding rate of 105 times higher than the test group (p < 0.001), no significant differences were observed on days 3 and 7. CONCLUSIONS: promotes wound healing and reduces discomfort and bleeding in the palatal donor area after FGG. TRIAL REGISTRATION NUMBER: NCT06610331; Retrospectively registered on 23/09/2024.

Source: BMC Oral Health

DOI: 10.1186/s12903-025-06677-w

Authors: Tugba Bulut, Nuray Ercan

Institution: Bolu Abant İzzet Baysal University

Language: English

Topic: Periodontal Regeneration and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190