Year: 2025
Type: article
Abstract: Childhood and adult patients with growth hormone deficiency (GHD) experience a variety of physical, metabolic, and psychological problems that collectively lower quality of life (QoL). Recombinant human growth hormone (rhGH) has transformed treatment by improving growth body composition, energy levels, and mental health. Nevertheless, further research is needed to determine the full scope of these QoL gains. This review of the literature summarizes current research on how growth hormone (GH) replacement therapy affects GHD patients' quality of life based on longitudinal studies, metaanalyses, and clinical trials. Although GH therapy has demonstrated advantages in several QoL areas, issues still exist, such as patient response variability, the sustainability of long-term treatment, and possible adverse effects. The effectiveness of GH therapy, the methods used to evaluate QoL outcomes, and the necessity of individualized treatment approaches are all clarified by this review's analysis of the most recent data. Future research should validate current QoL tools, assess the long-term safety of GH therapy, and develop improved methods for monitoring treatment outcomes to enhance personalized care and overall well-being in GHD patients.
Source: Journal of Healthcare Sciences
Authors: Abdullah Moneef AlMutairi, Mushabab Ali Alshahrani, Abdullah Sameer Basaba, Sabah Abdulrahman Al Royba, Abdulaziz Saad Alghamdi, Saeed Abdulsattar Mohammed, Khadejah Mofreh AlQahtani
Institutions: Security Forces Hospital, Ministry of Health
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4413059802