Rhodium(III)-catalyzed C-H annulation for the construction of antifungal agents based on isocoumarin framework
Year: 2025
Type: article
Abstract: A series of hydroxy- and alkoxy-substituted isocoumarins were synthesized in one step by the rhodium-catalyzed C-H annulation of benzoic acids with alkynes. 8,9-Diethyl-6H-[1,3]dioxolo[4,5-f]isochromen-6-one and its isoquinolone analog have effectively inhibited the growth of six types of phytopathogenic fungi at 30 mg dm--3 concentration, the activity exceeding that of the commercial Triadimefon.
Source: Mendeleev Communications
DOI: 10.71267/mencom.7777
Authors: Vladimir Borisovich Kharitonov, Olga G Chusova, Iolina O Bekshaite, Kirill A Vasiliev, Aleksei Nikolaevich Rodionov, Yulia Vladimirovna Nelyubina, Pavel Vladimirovich Dorovatovskii, Dmitry Alexandrovich Loginov
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
Awards: G1530898836, G8803236954
OpenAlex ID: W4413065013