Work

NLR Risk Score for Predicting Patient Prognosis in Hepatocellular Carcinoma and Identification of Oncogenic Role of NLRP5 in Hepatocellular Carcinoma

Year: 2025

Type: article

Abstract: Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths. The Nod-like receptor (NLR) family is involved in innate immunity and tumor progression, but its role in HCC remains unclear. This study aimed to evaluate the prognostic value and biological function of NLR genes in HCC. Methods: xenograft models. Results: . Mechanistically, NLRP5 modulated the p53 signaling pathway, influencing cell cycle and apoptosis. Conclusion: This study developed an NLR-based prognostic model that effectively stratifies HCC patients by survival risk. NLRP5 was identified as a novel oncogene promoting HCC progression via the p53 pathway, suggesting its potential as a therapeutic target.

Source: Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics

DOI: 10.32604/or.2025.067065

Authors: Mingyang Tang, Shengfu He, Bao Meng, Qingyue Zhang, Chengcheng Li, Yating Sun, Weijie Sun, Cui Wang, Qingxiang Kong, Yanyan Liu, Lifen Hu, Yufeng Gao, Qinxiu Xie, Jiabin Li, Ting Wu

Institutions: Anhui Medical University, First Affiliated Hospital of Anhui Medical University, Chaohu Hospital of Anhui Medical University

Language: English

Topic: Hepatocellular Carcinoma Treatment and Prognosis

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4413083386

FWCI: 0.497

Cites: 45

Cited by: 1

Related to: 10