Work

Successful use of human amniotic allograft membrane in the treatment of recalcitrant driveline infections

Year: 2025

Type: article

Abstract: Driveline infections represent a significant source of morbidity and mortality in left ventricular assist device (LVAD) patients. Driveline infection occur in up to 40% of cases and have recurrence rates up to 50%. Current literature fails to demonstrate specific interventions capable of reducing prevalence of recalcitrant driveline infections (including serial debridement, muscle flap coverage of the driveline, driveline relocation, and device exchange). Human cryopreserved decellularized amniotic membrane (HCDAM) has been effectively used in chronic non-healing infected diabetic ulcers and reconstructive orthopedic and ophthalmology surgery for its advantageous biological properties. With no univocal consensus treatment option, we firstly explored HCDAM application in recalcitrant driveline infection and we describe the successful outcome in a patient who failed previous management with serial debridement. By wrapping HCDAM around the driveline we were able to obtain a positive tissue response leading to infection resolution.

Source: JHLT Open

DOI: 10.1016/j.jhlto.2025.100351

Authors: Cristiano Spadaccio, Udit Vyas, Antonio Panza, Russell Samuel Vester, Louis Benson Louis IV

Institutions: University of Cincinnati, Wright State University

Language: English

Topic: Mechanical Circulatory Support Devices

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500