Work

Platelet Membrane Biomimetic Chemiluminescent Nanoparticles for Targeted Therapy of Atherosclerosis

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Photodynamic therapy (PDT) scavenges diseased cells by using photosensitizers, excitation light, and oxygen. Conventional PDT relies on external excitation light. The depth of penetration of the excitation light is limited, and atherosclerotic plaques are located deep in the tissue, which is not conducive to atherosclerosis treatment. In this study, self-luminescent nanoparticles, platelet membrane (PM)-coated PLGA nanoparticles containing the photosensitizer chlorin e6 (Ce6) and bis(2,4,5-trichloro-6-[pentyloxycarbonyl]phenyl)oxalate (BTPO) (PM@CBNP), are designed for atherosclerosis therapy. After PM@CBNP targeted the plaque, BTPO reacts with H 2 O 2, exciting Ce6 to generate singlet oxygen ( 1 O 2 ) in the atherosclerotic plaque with overexpressed H 2 O 2 . The targeting ability and chemiluminescence of PM@CBNP are investigated in vitro and in vivo. In atherosclerotic mice, PM@CBNP eliminate inflammatory macrophages, reduce the expression of inflammatory factors, and prevent the progression of atherosclerosis. PM@CBNP provide an idea for the therapy of atherosclerosis.

Source: ACS Applied Materials & Interfaces

DOI: 10.1021/acsami.5c10093

Authors: Qianru Zhou, Maoqing Huang, Yujie Wang, Dan Mu

Institutions: Nanjing University of Chinese Medicine, Nanjing Drum Tower Hospital, Jiangsu University, Tongji University, Shanghai Tenth People's Hospital

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500