Work

[Research progress on early-stage primary biliary cholangitis accompanied by portal hypertension].

Year: 2025

Type: article

Abstract: Primary biliary cholangitis (PBC) is a type of autoimmune liver disease characterized by chronic intrahepatic cholestasis. Although portal hypertension is a common complication in patients with cirrhotic PBC, portal hypertension and its related complications can occur in the early stage of the disease, that is, before the cirrhosis onset. Therefore, early identification and long-term management are of great significance to reduce the occurrence of portal hypertension and decompensation events and improve long-term prognosis in patients with PBC. This paper focuses on the epidemiology, pathophysiological mechanism, clinical characteristics, non-invasive diagnosis, and treatment strategies for portal hypertension in early-stage PBC patients.

Source: PubMed

DOI: 10.3760/cma.j.cn501113-20250505-00172

Authors: L Ma, L Shen, S X Li, W J Duan, J D Jia, H You

Institutions: Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital

Language: English

Topic: Liver Diseases and Immunity

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Natural Science Foundation for Young Scientists of Shanxi Province, Young Scientists Fund