Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: A combination of multiple nutritional indexes may more comprehensively and favorably reflect dialysis patient's prognosis. In the present study, we aimed to evaluated the association between total cholesterol/(body mass index × serum albumin) (TC/BA) and mortality in patients with continuous ambulatory peritoneal dialysis (CAPD). METHODS: We conducted a multicenter retrospective cohort study that included 2907 incident Chinese CAPD patients from seven peritoneal dialysis centers in China between January 1, 2005, and May 31, 2023. The primary outcome was all-cause mortality. We used restricted-cubic-spline plots to explore the shape of the association between TC/BA and outcome. Cause-specific hazard models examined the association between TC/BA and mortality. RESULTS: = 0.374). In the multivariate cause-specific hazard model, a per-1.0 increase of TC/BA had a 1.29-fold (95% confidence interval [CI] 1.19-1.39) risk of all-cause mortality in the total population. Similar trends were observed in subgroup analyses (all P for interactions > 0.05). Notably, the hazard ratio (HR) of TC/BA (per-1.0 increase) was 1.32 (95% CI 1.23-1.41), 1.29 (95% CI 1.19-1.41), and 1.25 (95% CI 1.22-1.27) times higher than the HR of body mass index (per-1.0 decrease), total cholesterol (per-10 increase), and serum albumin (per-1.0 decrease), respectively. CONCLUSIONS: TC/BA was positively linearly related to mortality and may outperform each index in assessing CAPD patient prognosis. The combined nutritional index may more comprehensively and favorably evaluate CAPD patients' prognosis.
Source: Renal Failure
Authors: Wenjun Lin, Juan Wu, Xiaojiang Zhan, Yueqiang Wen, Xiaoyang Wang, Xiaoran Feng, Fenfen Peng, Na Tian, Ning Su, Qingdong Xu, Niansong Wang, Xiangwei Liao, Xianfeng Wu
Institutions: Shanghai Jiao Tong University, Shanghai Sixth People's Hospital, Zhejiang Provincial People's Hospital, First Affiliated Hospital of Nanchang University, Second Affiliated Hospital of Guangzhou Medical University, First Affiliated Hospital of Zhengzhou University, Jiujiang First People's Hospital, Zhujiang Hospital, Southern Medical University, Ningxia Medical University, Ningxia Medical University General Hospital, Sixth Affiliated Hospital of Sun Yat-sen University, Jiangmen Central Hospital, Shanghai Eighth People Hospital
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,306
OpenAlex ID: W4413101599