High donor regulatory B cells (Bregs) and their rapid recovery are associated with protection from the development of acute graft‐versus‐host disease ( aGVHD ) following allogeneic hematopoietic stem cell transplantation
Year: 2025
Type: article
Study design: Observational Study
Abstract: regulatory B-cell (Breg) content and the Breg recovery rates during 90 days following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and their correlation with the development of acute graft-versus-host disease (aGVHD). Twenty-four donor-recipient pairs with hematological malignancies who underwent unmanipulated, fully HLA-matched allo-HSCT from related siblings were enrolled. The frequency of Bregs and their absolute number were significantly lower in donors whose recipients developed aGVHD (*p = 0.005 and *p = 0.016, respectively). Acute GVHD (+) patients had a significantly diminished percentages of Bregs recovered at days 60 and 90 compared to the aGVHD (-) ones (*p < 0.001 and *p = 0.002, respectively). A median donor Breg <1.85 as well as median Breg <1.92, <1.45, and <1.36 recovered on days 30, 60, and 90 were associated with a greater cumulative incidence of aGVHD (*p = 0.036, *p = 0.004 and *p = 0.006, respectively). Multivariate analysis revealed that infusion of grafts with a median Breg >1.85% decreased the risk of grades II-IV aGVHD (hazard ratio (HR) = 0.033, 95% confidence interval [CI] = 0.002-0.477; *p = 0.012). Our results revealed, for the first time, that high donor Breg content and their rapid recovery within 90 days after allo-HSCT were associated with a decreased risk of aGVHD.
Source: British Journal of Haematology
DOI: 10.1111/bjh.70058
Authors: Mani Ramzi, Maryam Hesamadini, Mohammadnabi Sanaei, Hossein Golmoghaddam, Mehdi Kalani, Nargess Arandi
Institutions: Shiraz University, Shiraz University of Medical Sciences
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Award: G4181279836
OpenAlex ID: W4413101964