Work

Oligothiophene-based photosensitizers with tunable push–pull architectures: design, synthesis and characterization

Year: 2025

Type: article

Abstract: = 4.0 nM for the most efficient PS) than common photosensitizers. Real-time fluorescence imaging revealed rapid membrane blebbing when the cells treated with HSA-OT were exposed to light, indicative of necrotic-like immunogenic cell death. Taken together, our findings highlight the power of molecular engineering in optimizing photosensitizer performance and provide proof of concept for the potential of HSA-OT conjugates as a multifunctional theranostic platform for cancer.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d5tb01076d

Authors: Soraia Flammini, Manuele Di Sante, Paolo Emidio Costantini, Edoardo Jun Mattioli, Alessia Marconi, Eleonora Turrini, Silvia la Rosa, Maria Montrone, Tainah Dorina Marforio, Michela Nigro, Nicol Spallacci, Alberto Zanelli, Mattia Zangoli, Alberto Danielli, Matteo Di Giosia, Francesca Di Maria, Matteo Calvaresi

Institutions: Institute of Organic Synthesis and Photoreactivity, National Research Council, University of Bologna

Language: English

Topic: Photodynamic Therapy Research Studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Fondazione Umberto Veronesi, Associazione Italiana per la Ricerca sul Cancro

Awards: G1158840576, G8495670555

OpenAlex ID: W4413102804

FWCI: 4.86

Cites: 35

Cited by: 8

Related to: 10