PLCγ has a dual role in capsaicin-triggered neurogenic inflammation promoting mechanical hypersensitivity and edema in male mice
Year: 2025
Type: article
Abstract: When activated, TRPV1 promotes neurogenic inflammation via neuropeptide signaling. However, drugs designed to directly block TRPV1 may impair its nociceptive roles, essential for tissue preservation. In this work, pain and swelling caused by neurogenic inflammation were mitigated after blocking PLCγ's activity, modulating TRPV1's activity without affecting normal chemosensitivity. This suggests that blocking PLCγ could be a new approach for the development of painkillers maintaining the physiological detection of harmful stimuli.
Authors: Alexandre M. do Nascimento, Ana M. Rodrigues, Heloisa E. G. Ramos, Beatriz C. de Moraes, Raphael S. Santos, Camila S. Dale, Deborah Schechtman
Institution: Universidade de São Paulo
Language: English
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4413106533