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Sex differences in ventricular repolarization during trigeminal nerve stimulation: insights into QT/RR hysteresis

Year: 2025

Type: article

Abstract: QT interval response to diving-induced bradycardia is delayed, a phenomenon known as QT/RR hysteresis. This study reveals sex-specific differences in the QT-HR relationship during simulated diving: women exhibit faster QT adaptation than men, suggesting a more robust repolarization response. These findings provide new insights into the sex-dependent dynamics of cardiac repolarization under autonomic conflict, with potential implications for arrhythmia risk assessment and cardiovascular protection during diving or aquatic sports.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00475.2025

Authors: Marcela S. Araújo, Adamor S. Lima, Rosa V. D. Guerrero, Lauro C. Vianna

Institution: Universidade de Brasília

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Physiological Society, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico