Work

Clinical characteristics and efficacy of short-course antibiotic therapy for Staphylococcus aureus bacteremia in hematological patients

Year: 2025

Type: article

Abstract: = 0.373). For hematological adult patients infected with SAB, MRSA, and polymicrobial infection associated with poor outcomes. Short-course antibiotic therapy for uncomplicated SAB seemed to yield similar clinical outcomes as long-course one. IMPORTANCE: bacteremia (SAB) in patients with hematological diseases. Some studies have suggested that short-course antibiotic therapy was feasible for uncomplicated SAB, but few have targeted hematological patients. Here, we described clinical characteristics and outcomes of SAB in hematological patients and highlighted advanced age, refractory or relapsed hematological diseases, and polymicrobial infection as independent predictors of 90-day mortality, while MRSA bacteremia was associated with early mortality risk. And we demonstrated that short-course antibiotic therapy (≤10 days) for uncomplicated SAB in hematological patients was non-inferior to long-course one (>10 days).

Source: Microbiology Spectrum

DOI: 10.1128/spectrum.02325-24