Work

Some New Zinc Halide Complexes of N 2 O 2 ‐Schiff Base: Synthesis, Thermal, Antimicrobial, Antioxidant, Anticancer and Burn Wound Healing Effects

Year: 2025

Type: article

Abstract: ABSTRACT A series of novel zinc(II) complexes derived from a tetradentate N 2 O 2 ‐Schiff base ligand were synthesized using zinc halide and pseudohalide salts with the general formula ZnLX 2 (X = Cl − , Br − , I − , N 3 − , SCN − ). The resulting compounds were thoroughly characterized by a range of spectroscopic and physicochemical techniques. Additionally, nanostructured zinc complexes such as ZnLBr 2 and ZnLI 2 were synthesized via an ultrasound‐assisted approach, with ZnLI 2 subsequently utilized as a precursor for the fabrication of ZnO nanoparticles. The nanostructures were confirmed by scanning electron microscopy (SEM), EDX, and x‐ray diffraction (XRD) analyses. Thermal decomposition studies of the ligand and its zinc complexes revealed two‐ to three‐step degradation processes, for which key thermokinetic parameters ( E *, Δ S* , Δ H * , A , and Δ G *) were determined. From a biological standpoint, the synthesized compounds displayed potent antimicrobial activity against selected Gram‐positive ( Staphylococcus aureus and Bacillus subtilis ) and Gram‐negative ( Pseudomonas aeruginosa and Escherichia coli ) bacterial strains, as well as fungal pathogens ( Aspergillus oryzae and Candida albicans ). DNA cleavage assays further confirmed the nucleolytic potential of these complexes. Selected compounds demonstrated noteworthy cytotoxic effects against the PC3 human prostate cancer cell line, substantiating their anticancer capabilities. Antioxidant properties were evaluated using DPPH (2,2‐diphenyl‐1‐picrylhydrazyl) and FRAP (ferric reducing antioxidant power) assays, exhibiting promising radical‐scavenging activity. Notably, the ligand and ZnLI 2 complex also exhibited significant efficacy in promoting burn wound healing, highlighting their therapeutic potential in both infectious and regenerative medicine.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202500817

Authors: Ameneh Malekhoseini, Morteza Montazerozohori, Reza Naghiha, Esmaeel Panahi Kokhdan, Shima Hosseinifar

Institutions: Yasouj University, Shahid Chamran University of Ahvaz, Yasuj University of Medical Sciences

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Yasuj University of Medical Sciences, Yasouj University