Work

Amorphous‐Crystalline Synergy in CoSe2/CoS2 Heterostructures: High‐Performance SERS Substrates for Esophageal Tumor Cell Discrimination

Year: 2025

Type: article

Abstract: Although surface‐enhanced Raman scattering (SERS) spectroscopy is applied in biomedicine deeply, the design of new substrates for wider detection is still in demand. Crystalline‐amorphous CoSe2/CoS2 heterojunction is synthesized, with high SERS performance and stability, composed of orthorhombic (o‐CoSe2) and amorphous CoS2 (a‐CoS2). By adjusting feed ratio, the proportion of a‐CoS2 to o‐CoSe2 is regulated, where CoSe2/CoS2‐S50 with a 1:1 ratio demonstrates the best SERS performance due to the balance of two components. It is confirmed through experimental and simulation methods that o‐CoSe2 and a‐CoS2 have unique contribution, respectively: a‐CoS2 has rich vacancies and a higher density of active sites, while o‐CoSe2 further enriches vacancies, enhances electron delocalization and charge transfer (CT) capabilities, and reduces bandgap. Besides, CoSe2/CoS2‐S50 achieves not only SERS detection of two common esophageal tumor cells (KYSE and TE) and healthy oral epithelial cells (het‐1A), but also the discrimination with high sensitivity, specificity, and accuracy via machine learning (ML) analysis.

Source: Small

DOI: 10.1002/smll.202507530