Diagnostic values of the monocyte to hemoglobin ratio and neutrophil–lymphocyte ratio to albumin ratio in non-small cell lung cancer
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To evaluate the diagnostic utilities of monocyte to hemoglobin ratio (MHR) and neutrophil-lymphocyte ratio to albumin ratio (NLRAR) in the detection of non-small cell lung cancer (NSCLC). METHODS: We retrospectively collected and analyzed the clinical and laboratory data, including 196 NSCLC cases and 204 controls. RESULTS: The area under the curve (AUC) for 95% confidence interval (95% CI) of MHR and NLRAR in the diagnosis of NSCLC were found to be 0.822 (0.781-0.864) and 0.712 (0.662-0.762), respectively. The combined use of MHR, NLRAR, and carcinoma embryonic antigen (CEA) exhibited higher diagnostic sensitivity (AUC: 0.855; 95% CI: 0.818-0.892; sensitivity: 70.4%; specificity: 89.2%) than the use of individual markers or two markers combined. MHR was a potential biomarker to detect early-stage NSCLC. CONCLUSIONS: MHR and NLRAR are effective auxiliary biomarkers to predict the presence of NSCLC. When these markers are combined with CEA the diagnostic effects will further improve.
Source: Indian Journal of Cancer
Authors: Si-Ting Zhao, Fen-Hong Qian
Institutions: Jiangsu University, Affiliated Hospital of Jiangsu University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4413108660