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Taurine as a Protective Metabolite in Radiation-Induced Liver Disease: Evidence from 1H NMR Metabolomics

Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Radiation therapy for liver and upper abdominal malignancies is associated with a high risk of radiation-induced liver disease (RILD), often involving metabolic disturbances. This study aimed to characterize metabolomic alterations in a murine RILD model using 1 H-nuclear magnetic resonance (NMR) spectroscopy. RILD was induced in mice via 15 Gy hepatic irradiation. Liver tissues were subjected to time-course metabolomic profiling using 1 H NMR. Validation was performed through liver enzyme assays, histological analysis, and qPCR. Taurine was selected for therapeutic evaluation based on metabolomic findings. Significant reductions in glutathione and pyruvate levels were observed in the acute stage, whereas increases in phenylalanine and tyrosine levels were observed in the chronic stage. These metabolite alterations were correlated with reactive oxygen species (ROS) production, glycolysis modulation, and fibrosis progression in RILD. Notably, taurine levels increased during the acute stage but decreased during the chronic stage. Furthermore, in mice at 12 weeks postirradiation, taurine supplementation maintained liver enzyme activity, cytokine profiles, and taurine metabolism at levels similar to those of the control group. In conclusion, this study revealed dynamic metabolic changes associated with physiological alterations in a murine RILD model and identified, through 1 H NMR metabolomics, taurine as a potential target for alleviating nonclassical RILD symptoms.
DOI: 10.1021/acs.jproteome.5c00398
Authors: Yi-Hsiu Chung, Chi-Chang Weng, Fujie Jhang, Gigin Lin, Ching-Fang Yu, Fang-Hsin Chen
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: National Science Council, Chang Gung University, Chang Gung Medical Foundation, Ministry of Science and Technology, Taiwan, National Tsing Hua University, Ministry of Science and Technology of Thailand, National Science and Technology Council
Awards: G1040028732, G1155756365, Assessment of the Early and Late Response to Proton Therapy in Hcc Mice with the Multimodalities Spect/Pet/Mri, and Combined Target Therapy Mtor Inhibitor to Improve the Treatment Efficacy, G315870435, G4932773083, G5061810521, G5149572241, G6200933118, G6879487567, G7118462656, G7640746446, G8073280996, G8136449526, G8481648534, G8771169932, G8914249219
OpenAlex ID: W4413109259
FWCI: 0.545
Cites: 41
Cited by: 1
Related to: 10