Work

Hepatic metastasis of pulmonary large cell neuroendocrine carcinoma: A case report and literature review

Year: 2025

Type: article

Abstract: Large cell neuroendocrine carcinoma of the lung is a rare and aggressive malignancy with a high propensity for metastasis. This carcinoma demonstrates a significantly higher propensity for hepatic metastasis compared with other non-small cell lung cancer subtypes, thereby exacerbating therapeutic complexity and worsening prognosis. A man in his early 60s was admitted to our institution with a hepatic space-occupying lesion. Hepatic segmentectomy was performed, and histopathological examination confirmed a neuroendocrine carcinoma. Following stabilization of vital signs, the patient underwent uniportal video-assisted thoracoscopic surgery for partial lobectomy of the right upper lung. Subsequent histopathological analysis confirmed the diagnosis of hepatic metastasis originating from pulmonary large cell neuroendocrine carcinoma. This case highlights that clinicians should maintain a high index of suspicion for large cell neuroendocrine carcinoma when encountering multifocal malignancies.

Source: Journal of International Medical Research

DOI: 10.1177/03000605251365855

Authors: Jiake Wu, Yang Cai, Bei Lu, Yanan Xu, Jianyong Zhuo, Junjie Yin

Institutions: Zhejiang Chinese Medical University, Westlake University, Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine

Language: English

Topic: Metastasis and carcinoma case studies

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,155