Work

Mechanistic insights into heart failure induction in ovariectomized rats: The role of mitochondrial dysfunction

Year: 2025

Type: article

Abstract: BACKGROUND: Premature menopause is recognized as a factor that increase the risk of heart failure (HF). However, the fundamental pathophysiology concerning cardiac dysfunction remains inadequately understood. METHODS: This study investigated whether cardiac function was altered in ovariectomy (OV) rats compared to controls. Female rats (n = 12) were randomly assigned into 2 groups: control (sham operation) and bilateral OV group. RESULTS: The echocardiographic analysis revealed that the E and E/A were significantly decreased, while the deceleration time was significantly increased in the OV group compared to the control group, indicating the presence of HF in the OV rats. ATP levels in the myocardium were significantly decreased, and oxidative DNA damage was elevated in the OV group compared to the control group. Furthermore, the mRNA levels of peroxisome-proliferator-activated receptor-gamma (PPARγ) co-activator-1 alpha (PGC-1α) and CR6 interacting factor 1 (Crif1) were reduced in the OV group. CONCLUSION: These findings suggest that OV may induce HF through mechanisms linked to mitochondrial dysfunction.

Source: Medicine

DOI: 10.1097/md.0000000000043709

Authors: Ki-Woon Kang, Seong-Kyu Lee

Institutions: Chung-Ang University Hospital, Chung-Ang University Healthcare System, Chung-Ang University, Eulji University, Daejeon Eulji Medical Center, Eulji University

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950