Work

The death of a myth: Females are not resistant to acute kidney injury

Year: 2025

Type: article

Abstract: There is an important gap of knowledge regarding the mechanisms behind the greater prevalence of chronic kidney disease (CKD) in females compared with males. Most of the published reports suggest that females are protected from acute kidney injury (AKI) and from the AKI-to-CKD transition; however, in this issue of Clinical Science, Moronge et al. demonstrate that female rats present with subclinical markers of kidney damage post-ischemic reperfusion injury despite normalized levels of plasma creatinine. These studies underscore the potential for this AKI-induced subclinical injury to underlie the higher sensitivity of females to develop CKD later in life.

Source: Clinical Science

DOI: 10.1042/cs20257005

Authors: Brian Soto Miranda, Carmen De Miguel

Institutions: Ponce Health Sciences University, University of Alabama at Birmingham, UAB Medicine

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Diabetes and Digestive and Kidney Diseases