Work

Mendelian randomization reveals a causal link between age at menarche and reduced risk of periodontitis

Year: 2025

Type: article

Abstract: The aim of this study was to assess the causal association between age at menarche (AAM) and periodontitis by use of a 2-sample 2-way Mendelian randomization (MR) study. A 2-sample bidirectional MR analysis was performed based on genome-wide association study data from European populations of AAM and chronic periodontitis, using single nucleotide polymorphisms as instrumental variables. Inverse-variance weighting, weighted median, weighted multinomial, and MR-Egger were used to assess the bidirectional causal association between AAM and chronic periodontitis. The inverse-variance weighting method showed a significant negative correlation between genetically predicted AAM and chronic periodontitis (odds ratio: 0.733; 95% confidence interval: 0.583-0.922; P = .0081), Cochran Q test showed no heterogeneity, MR-Egger showed there was no pleiotropic, leave-one-out confirmed the robustness of the results, and reverse MR analysis demonstrated no reverse causality. AAM may be negatively associated with chronic periodontitis.

Source: Medicine

DOI: 10.1097/md.0000000000043700

Authors: Yan Hou, Weilun Cai, Hua Xu, Jiandong Ban

Institutions: Hebei Eye Hospital, Nanfang Hospital, Southern Medical University

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,950