Work

Transcription factor Yin-Yang 1 governs cardiac metabolic reprogramming in response to exercise or pathological stress

Year: 2025

Type: article

Abstract: We are the first to demonstrate that YY1 is essential for cardiac energetic regulation using a cardiac-specific YY1 KO mouse model. Furthermore, we discovered that YY1's regulation of metabolic gene transcription is modulated by the epigenetic proteins p300 and HDAC. This mechanism may contribute to the differences in cardiac energetic regulation in response to exercise versus pathological stress.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00419.2025

Authors: Manling Zhang, Zishan Peng, Haiqin Ping, Zoe Li, Jia-Jun Liu, Silvia Liu, Ning Feng

Institutions: University of Pittsburgh, VA Pittsburgh Healthcare System

Language: English

Topic: Cardiovascular and exercise physiology

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Heart Association, University of Pennsylvania, Harvard University, University of Pittsburgh, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Mettl14 governs cardiomyocyte maturation, G3075075058, Advanced High Resolution Rodent Ultrasound Imaging System, G5023073700, Epigenetic reprogramming of cardiac macrophages to promote cardiac regeneration, The role of transcription factor Ying-Yang 1 in the cardiac bioenergetics regulation, G8629291795

OpenAlex ID: W4413114688

FWCI: 5.158

Cites: 23

Cited by: 5

Related to: 10