Work

Stress during pregnancy alters hepatic renin-angiotensin system and redox homeostasis in a sex- and age-specific manner

Year: 2025

Type: article

Abstract: Prenatal stress may contribute to sex- and age-specific programming of the liver in adult offspring. Our results showed that stress during pregnancy alters the hepatic renin-angiotensin system only at 120-days old and specially in male offspring. Furthermore, the prenatal stress leads to redox imbalances in females at 90 days and remaining at 120 days old independently of the renin-angiotensin system.

Source: American Journal of Physiology-Gastrointestinal and Liver Physiology

DOI: 10.1152/ajpgi.00142.2025

Authors: Gabriel Fernandes Teixeira, Juliana Mentzinger, Juliana Arruda de Souza Monnerat, Bianca Bittencourt Lucchetti, Mariana Silva Cytrangulo, Luiza Rocha, Lívia Alves de Oliveira, Matheus Alves Bittencourt, Renata Frauches Medeiros, Antonio Claudio Lucas da Nóbrega, Helena Naly Miguens Rocha, Natália Galito Rocha

Institution: Universidade Federal Fluminense

Language: English

Topic: Birth, Development, and Health

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro

Awards: G2687170136, G4801965650, G5791307865

OpenAlex ID: W4413114694

FWCI: 2.804

Cites: 44

Cited by: 2

Related to: 10