Work

Identification of characteristic genes ofanddeficiency constitutions: an integrated analysis based on bioinformatics and machine learning.

Year: 2025

Type: article

Abstract: OBJECTIVE: deficiency constitutions, which serve as key references for disease prevention and management. METHODS: deficiency constitution were validated using external datasets. Receiver operating characteristic (ROC) analysis was used on each hub genes of the two groups to further understand their diagnostic performance. The miRNA-lncRNA-gene network was used to further analyze the hub genes. Immunoinfiltration and gene set enrichment analysis were performed on the shared hub genes. RESULTS: deficiencies. CONCLUSIONS: deficiency as potential biomarkers, providing insights into their pathogenesis. This theory not only guides the diagnostic approach in TCM but also extends its influence to various scientific research fields.

Source: PubMed

DOI: 10.19852/j.cnki.jtcm.2025.04.021

Authors: Long Xi, W U Zixuan, Y U Yunfeng, Lin Jie, Peng Qinghua

Institutions: Hunan University of Traditional Chinese Medicine, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine

Language: English

Topic: Traditional Chinese Medicine Studies

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4413116330

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