Work

Feasibility of lock solutions for epicutaneo-caval catheters in neonates: the ‘LOOSEN’ pilot study

Year: 2025

Type: article

Abstract: Epicutaneo-caval catheters are vital in neonatal care, but are prone to occlusion and infection. This pilot study evaluated whether a 1-h saline lock, combined with proper flushing and anti-reflux connectors, affects catheter patency in neonates. Catheter patency was assessed using infusion pressure (pre- and post-lock) as a surrogate measure. The findings support the feasibility and safety of short lock periods, thereby laying the groundwork for future use of antimicrobial lock solutions in neonatal care.

Source: Journal of Hospital Infection

DOI: 10.1016/j.jhin.2025.07.014

Authors: V. D'Andrea, G. Prontera, G. Vento

Institution: Agostino Gemelli University Polyclinic

Language: English

Topic: Central Venous Catheters and Hemodialysis

Subfield: Emergency Medical Services

Field: Health Professions

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,000