Work

The Early Effects of Esketamine on the Tumor Metastatic Microenvironment in Postoperative Lung Cancer Patients

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: ABSTRACT Background To investigate the early effect of esketamine on the tumor metastatic microenvironment in patients with lung cancer. Methods Sixteen adults aged 45–80 years with the American Society of Anesthesiologists (ASA) 1 to 3 were randomly divided into the experimental group (group E) and the control group (group C). Group E received esketamine at 1 mg/kg during anesthesia induction and a continuous infusion of 0.5 mg/kg/h during the surgery. Group C was given the same amount of normal saline infusion. Patient‐controlled intravenous analgesia (PCIA) in group E was administered using dexmedetomidine (0.5 mg/kg) + esketamine (50 mg) + dexamethasone (5 mg). PCIA in group C was the same dose of dexmedetomidine and dexamethasone. Data were recorded at 14 points from admission to the third day after surgery (T0–14). Parameters recorded included hemodynamics, wake time, remifentanil dosage, and so on. At T0, T10, T13, and T14, TNF‐α, IL‐2, IL‐10, MMP‐9, and VEGF‐C were measured. Results Compared with T0, the differences of tumor necrosis factor‐α (TNF‐α), interleukin‐2 (IL‐2), matrix metallopeptidase 9 (MMP‐9), and vascular endothelial growth factor‐C (VEGF‐C) in the two groups were statistically significant (p < 0.05). When compared to group C, VEGF‐C in group E was reduced at T10 and T13 (p < 0.05). For both groups, there were intragroup differences in the changes of MMP‐9 and VEGF‐C levels (p < 0.05). Compared to group C, on the postoperative, group E exhibited a lower change rate of TNF‐α and VEGF‐C (p < 0.05). Conclusion Perioperative application of esketamine in patients with lung cancer provided significant sedative and analgesic effects and affected cytokines in the tumor microenvironment.

Source: The Clinical Respiratory Journal

DOI: 10.1111/crj.70108

Authors: Yong Wang, Weijing Li, Li Jia, Junmei Shen, Chao Li, Huiqun Jia

Institutions: Hebei Medical University, Fourth Hospital of Hebei Medical University

Language: English

Topic: Cancer, Stress, Anesthesia, and Immune Response

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,310