Work

Mimicking scaffold membrane based electrospun polyurethane fibers with functional extracellular-like component coating for guided bone regeneration scaffolds

Year: 2025

Type: article

Abstract: • A tissue scaffold was created as biomaterials supporting to guided bone regeneration. • A tissue scaffold was fabricated with mimicking electrospun PU incorporated with ECM-like materials. • Mimicking PU scaffold exhibited structure and function-like ECM. • Mimicking PU scaffold had performance promising to guided bone regeneration. Mimicking scaffold membranes for guided bone regeneration were fabricated using electrospun polyurethane (PU) coated with polyvinyl alcohol (PVA) and sodium alginate. Five different proportions of PVA and sodium alginate (AGN) were compared as coating solutions for the electrospun PU membranes. Molecular organization, morphology, and physical, mechanical, and biological properties were investigated. The results demonstrated that the electro-spun PU membranes with PVA and sodium alginate coating showed molecular organization via chemical bonding. The coated membranes, especially PU/PVA:AGN (30:70), exhibited higher hydrophilicity, maximum load, and elasticity than membranes without coating, and they exhibited better cell adhesion, cell proliferation, ALP activity, and calcium deposition. In conclusion, we determined that our PU/PVA:AGN (30:70) periosteum mimicking membrane is a promising candidate for guided bone regeneration applications.

Source: Biomaterials and Biosystems

DOI: 10.1016/j.bbiosy.2025.100116

Authors: Nattawat Watcharajittanont, Worasak Prarokijjak, Chayada Teanchai, Kanon Jatuworapruk, Jirut Meesane

Institutions: Thammasat University, Mahidol University, Prince of Songkla University

Language: English

Topic: Electrospun Nanofibers in Biomedical Applications

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,340