Year: 2025
Type: article
Study design: Observational Study
Abstract: Aim. To study the potential of early diagnostics of cardiac autonomic dysfunction (CAD) in patients with systemic sclerosis (SSc). Material and methods. The case-control study included 41 patients with SSc and 19 healthy individuals. Clinical tests (deep breathing test, blood pressure and heart rate (30:15) response to the orthostatic test) were performed, and patients were surveyed using the Composite Autonomic Symptom Score-31 (COMPASS-31) questionnaire. Results. The total COMPASS-31 score in patients with SSc was 24,6 [13,6; 37,6], in the control group — 13,8 [2,7; 32,8] (p=0,021). The combination of vasomotor and orthostatic disorders was observed more often in patients with SSc than in the control group — in 23 (56,1%) and 3 (15,8%) participants, respectively (OR — odds ratio) =6,82; 95% confidence interval (CI): 1,72-27,06; p=0,003. In patients with SSc, the 30:15 ratio (heart rate response to orthostatic test) was significantly lower than in the control group (p=0,001); pathological test results indicating CAD were more often observed in patients with SSc (OR=6,50; 95% CI: 1,26-33,58; p=0,016). A positive correlation was found between the total COMPASS-31 score and the duration of SSc from the disease onset, diagnosis, and the duration of Raynaud's syndrome (R=0,39, R=0,35, R=0,38, p<0,05). Conclusion. Patients with SSc show following early signs of CAD: vasomotor and orthostatic disorders are recorded 6,8 times more often according to the COMPASS-31 questionnaire, and pathological results of the 30:15 clinical test are detected 6,5 times more often.
Institution: Pirogov Russian National Research Medical University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4413129371