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Unexpected CA 19–9 Elevation in a Patient With a Splenic Epithelial Cyst: A Diagnostic Challenge

Year: 2025

Type: article

Abstract: Splenic epithelial cysts are rare, benign lesions often discovered incidentally. Although typically asymptomatic, they can sometimes present with elevated tumor markers, such as CA 19-9, raising concerns for malignancy. We report the case of a 44-year-old woman who was found to have elevated liver enzymes and CA 19-9 levels. Imaging revealed a unilocular splenic cyst. Laparoscopic splenectomy was performed, and histopathology confirmed a benign epithelial cyst. Postoperatively, CA 19-9 levels declined significantly. This case highlights the importance of considering benign etiologies in patients with elevated tumor markers and emphasizes the role of imaging and surgical pathology in establishing a diagnosis.

Source: Cureus

DOI: 10.7759/cureus.89697

Authors: Mohammed A Alsuhaimi, Mohmmed A AlHewishel, May S AlKhaldi, Abdurahman S AlSumaihi, Khaled S Albahout

Institution: King Fahd Hospital of the University

Language: English

Topic: Abdominal Trauma and Injuries

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4413130847