Impaired central thyroid hormone sensitivity is associated with time in range in patients with type 2 diabetes mellitus in the euthyroid population
Year: 2025
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To investigate the correlation between central thyroid hormone (TH) sensitivity and time in target glucose range (TIR) in patients with type 2 diabetes mellitus (T2DM). METHODS: 483 enrolled inpatients with T2DM were collected with the continuous glucose monitoring (CGM) data and clinical characteristics. Thyroid stimulating hormone index (TSHI), thyrotropin-thyroxine resistance index (TT4RI) and thyroid feedback quantile index (TFQI) were calculated. The correlations between TSHI, TT4RI, TFQI and TIR were statistically analyzed. RESULTS: The levels of FT4, TSHI, TT4RI and TFQI in TIR > 70% group were all higher compared with TIR ≤ 70% group (all P < 0.05). TSHI was positively correlated with TIR before the inflection point of 2.2 (β = 14.8, P < 0.001), and the correlation strengthened after there (β = 30.9, P < 0.001). TT4RI was positively correlated with TIR before the inflection point of 32 (β = 1.3, P < 0.001), and the correlation weakened after there (β = 0.7, P < 0.001). TFQI was not correlated with TIR before the inflection point of -0.6 (P = 0.302), but was positively correlated with TIR after there (β = 28.7, P < 0.001). For one-quartile increase in TSHI and TFQI, the odds of TIR-target (TIR > 70%) increased by 0.825 times and 1.3891 times respectively. CONCLUSION: Decreased central TH sensitivity, namely increased TH resistance, is associated with elevated TIR, suggesting that central TH resistance maybe a protective factor for TIR.
Source: Diabetology & Metabolic Syndrome
Authors: Xu Jiang, Yu Gong, Guojuan Wang, Ying Li
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,890
OpenAlex ID: W4413137642