Cushing's Syndrome Presenting with Depression asthe Initial Manifestation: A Case Report andLiterature Review
Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND: In approximately 12% of Cushing's syndrome (CS) cases, psychiatric symptoms, such as depression and anxiety, are the initial manifestation, obscuring the diagnosis and leading to delayed treatment. CASE SUMMARY: This case report describes a patient whose initial symptom of CS was low mood. Eighteen months later, typical clinical features of CS emerged, and the diagnosis was confirmed through dexamethasone suppression tests and adrenal computed tomography. This report also reviews relevant literature, analyzing the clinical features, pathogenesis, treatment, and prognosis of CS. CONCLUSION: In patients presenting with low mood or depression but no typical CS features, clinicians should consider CS as a potential underlying cause. Endocrinologists should be vigilant when evaluating patients with mental disorders. Timely diagnostic evaluations can lead to earlier diagnosis and treatment, ultimately improving prognosis.
Authors: Xiuli Xu, Baoqiang Guo, Xuexiu Chi
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4413137708