Work

Discovery of Rigid Linker-Based IRAK4 PROTACs with Improved Metabolic Stability for the Treatment of Inflammatory Diseases

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01620

Authors: Yapeng Fan, Rongxiang Ma, Kabonde Makasa Njobvu, Yifan Wang, Yichang Ren, Renquan Fu, Chenyu Zhang, Feifei Liu, Zhongping Jiang, Yong Rao, Congjun Xu, Ling Huang, Jianjun Chen, Jin Liu

Institutions: Hainan University, Southern Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Chest Hospital, Guangzhou Medical University

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Natural Science Foundation of Hainan Province, Hainan University, Guangzhou Science and Technology Program key projects

Awards: G1312751387, G293429392, G7227208562, 调控固有免疫的STING蛋白降解剂设计、合成及其急性肾损伤治疗研究

OpenAlex ID: W4413138002

FWCI: 2.872

Cites: 43

Cited by: 11

Related to: 10