The senescence-inducing factor IGFBP7 and risk of atrial fibrillation: findings from the PREVEND study
Year: 2025
Type: article
Study design: Observational Study
Abstract: Experimental evidence supports the role of cellular senescence in the pathophysiology of atrial fibrillation (AF) and suggests that Insulin-like Growth Factor Binding Protein-7 (IGFBP7) is an important senescence-inducing factor. Whether elevated IGFBP7 levels precede the development of AF remains unknown. We measured IGFBP7 levels in plasma of 5884 adult participants without prevalent AF (mean age 53.6 ± 12.1 years; 51.5% women) from the PREVEND community-based cohort (2001-2004). Incident AF was ascertained from hospital and study electrocardiograms. During a median follow-up of 6.4 (5.9-6.9) years, 154 participants (2.6%) developed AF. In Cox proportional hazards models, IGFBP7 was associated with increased risk for incident AF (unadjusted hazard ratio [HR]: 1.85 per 1-SD increase in log-IGFBP7; 95% confidence interval [CI]: 1.65-2.07) which remained significant after adjustment for clinical variables (HR: 1.28; 95% CI: 1.07-1.52). Based on these data, we conclude that IGFBP7, a senescence-inducing factor, is associated with the risk of developing AF in community-dwelling adults.
Source: npj Cardiovascular Health
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
Awards: G1048958618, G1276028933, G1437090616, G2232035207, G232572082, G2495375376, G2499554721, G2804631450, G3491308472, G3715656794, G389318308, G434337789, G4563062054, G4652779849, Fostering a European Research Area for Health Research, G5253191135, G5330491244, Addressing multimorbidity in elderly atrial fibrillation patients through interdisciplinary, tailored, patient-centered care pathways, G5605945002, G7040293956, G729854042, G7345595312, G7373087131, G7955819609, G8733705901, G883608875
OpenAlex ID: W4413138134