Hepatopathy in a 4-Month-Old Holstein Calf After Transfusion With Plasma Containing Bovine Bosavirus
Year: 2025
Type: article
Abstract: We report on the identification of bovine bosavirus associated with a post-transfusion hepatopathy in a 4-month-old Holstein bull calf that was referred for enteritis and fever of unknown origin. Next-generation sequencing (NGS) of post-transfusion blood and liver tissue from the calf, alongside NGS of plasma from the donor, identified a bovine bosavirus. This virus has been previously identified in bovine calf serum, calves with mucosal disease, and the blood of bison but was of uncertain clinical importance. These findings have biosecurity implications for clinicians using bovine whole blood or plasma therapeutically and suggest the need for pre- or postharvest donor screening or biologic processing to prevent infection of recipients. The calf made a full clinical recovery.
DOI: 10.1111/jvim.70208
Authors: Simon F. Peek, Chelsea L. Holschbach, Alexandra J. Burton, Zuzanna W. Sikorska, LaTasha K. Crawford, Christopher D. Dunn, Tony L. Goldberg
Institution: University of Wisconsin–Madison
Language: English
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,000
OpenAlex ID: W4413138176