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Rest, then rejuvenate: CD19 boost to improve CAR persistence

Year: 2025
Type: editorial
Abstract: In this issue of Blood, Annesley et al demonstrate durable leukemia-free remissions after SCRI-CAR19 (autologous CD19.4-1BB chimeric antigen receptor T cell) in a multicenter phase 2 trial, with particularly striking results in patients with low disease burden.The authors also show that a novel approach to boost CD19 antigen can improve chimeric antigen receptor T-cell (CAR-T) activity in those predicted to have short persistence.1
Source: Blood
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: bronze
OpenAlex ID: W4413138410
Cites: 8
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Related to: 10