Analysis of three cases of disseminated BCG infection in infants after BCG vaccination in Beijing, China
Year: 2025
Type: article
Study design: Case Report
Abstract: We report and analyze three cases of disseminated BCG infection in infants after BCG vaccination that occurred between 2022 and 2024 in Chaoyang District, Beijing, which were the only three monitored during the clinical application we conducted. All the patients had primary immunodeficiency disease (PID). Two cases had defects in the JAK3 and TNFRSF13B genes; one case had multiple gene defects in CR2, IFNAR2, TLR2, and exon 13 of DOCK11. Disseminated BCG infection is a rare adverse reaction after BCG vaccination. It occurs almost exclusively in immunodeficient infants or children. Although it rarely occurs, it is necessary to pay more attention to clinical practice because of its serious consequences.
Authors: Li Li, Jingyi Xu, Jianlin Cai, Mei Wang, Fang Wang, Liqing Yang, Yunhua Bai, Bin Jia, Shuping Li
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,175
OpenAlex ID: W4413138471